A pituitary tumor or other type of brain tumor located near the pituitary gland may cause testosterone or other hormone deficiencies.Īlso, treatment for a brain tumor, such as surgery or radiation therapy, can affect the pituitary gland and cause hypogonadism. An abnormality in the pituitary gland can impair the release of hormones from the pituitary gland to the testicles, affecting normal testosterone production. This abnormality can also affect the ability to smell (anosmia) and cause red-green color blindness. This is an abnormal development of the area of the brain that controls the secretion of pituitary hormones (hypothalamus). A number of conditions can cause secondary hypogonadism, including: ![]() In secondary hypogonadism, the testicles are normal but don't function properly due to a problem with the pituitary or hypothalamus. The effects of both treatments often are temporary, but permanent infertility may occur.Īlthough many men regain their fertility within a few months after treatment, preserving sperm before starting cancer therapy is an option for men. Chemotherapy or radiation therapy for the treatment of cancer can interfere with testosterone and sperm production. Damage to one testicle might not impair total testosterone production.Ĭancer treatment. Damage to both testicles can cause hypogonadism. Because they're outside the abdomen, the testicles are prone to injury. Too much iron in the blood can cause testicular failure or pituitary gland dysfunction, affecting testosterone production. A mumps infection involving the testicles that occurs during adolescence or adulthood can damage the testicles, affecting the function of the testicles and testosterone production. If not corrected in early childhood, it can lead to malfunction of the testicles and reduced production of testosterone. This condition often corrects itself within the first few years of life without treatment. Sometimes one or both of the testicles aren't descended at birth. ![]() ![]() Before birth, the testicles develop inside the abdomen and normally move down into their permanent place in the scrotum. The extra X chromosome that occurs in Klinefelter syndrome causes abnormal development of the testicles, which in turn results in underproduction of testosterone. The Y chromosome contains the genetic material that determines the sex of a child and related development. In Klinefelter syndrome, two or more X chromosomes are present in addition to one Y chromosome. A male normally has one X and one Y chromosome. This condition results from a congenital abnormality of the sex chromosomes, X and Y. Common causes of primary hypogonadism include:
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